May help support the normal conversion of homocysteine to methionine
May help support healthy methylation and metabolism
May help support cognitive health
May help support healthy energy levels
Active B12 5000 by Seeking Health provides two active "coenzyme" forms of vitamin B12, methylcobalamin and adenosylcobalamin, in a high-potency, easy-to-take lozenge form.
As "coenzyme" forms, methylcobalamin and adenosylcobalamin are the forms required by certain B12-dependent enzymes and reactions within the body. Vitamin B12 is required for proper red blood cell formation, neurological function, and DNA synthesis.
Vitamin B12 functions as a cofactor for methionine synthase and L-methylmalonyl-CoA mutase. Methionine synthase catalyzes the conversion of homocysteine to methionine. Methionine is required for the formation of SAMe (S-adenosylmethionine), an important methyl donor.*
Vitamin B12 is naturally present in seafood, shellfish, liver, eggs and dairy products. It may be harder for vegetarians and vegans to meet their daily needs for vitamin B12 from food sources without relying on supplements or fortified foods.
Typical absorption of vitamin B12 is facilitated by intrinsic factor (IF), a natural protein produced by the parietal cells of the stomach lining. Higher doses of vitamin B12 may be supportive for individuals with lower IF levels, as large doses of B12 may be able to use absorption mechanisms that do not rely on intrinsic factor.